A Nubiance lab innovation, ACT-5 is an exclusive formula initially developed for mixed to dark skin prone to acne. These skins are likely to develop brown spots resulting from post-inflammatory hyperpigmentation following acne. In use, the effectiveness of ACT-5 has proven to be remarkable whatever the ethnicity of the users and their geographical area. Therefore, ACT-5 is proposed indiscriminately for young and mature, light or dark skins, provided they are predisposed to hyperseborrhea.
ACT-5 acts biologically on the causes and consequences of acne. The unique combination of dermatological active ingredients reteaches the skin to regulate the quality and quantity of its fatty acids, to regain a sebum close to that of healthy skin and effectively prevent the appearance of pimples and blackheads.
The effectiveness of ACT-5 is based on three complementary ingredients that act on the causes and consequences of acne and help preserve the integrity and functionality of sebum. These three ingredients are:
Sytenol® A (bakuchiol):
Acting on lipid homeostasis, bakuchiol is a natural alternative substance to retinol, a powerful lipo-peroxidation inhibitor. It ensures the preservation of sebum by opposing the oxidation of squalene, thus preventing the appearance of pro-inflammatory mediators. It inhibits the development of P acnes (Propionibacterium acnes). For more information on bakuchiol, click here.
Hydrasynol® IDL (isosorbide dilinoletate):
Patented molecule resulting from green and sustainable chemistry, it acts on the homeostasis of the skin barrier. It regulates hydration by the filaggrine route, a precursor of natural hydration factors. It contributes to the preservation of the barrier functions.
Synovea® HR (hexylresorcinol):
Powerful inhibitor of melanin production by the tyrosinase and peroxidase pathways to control post-inflammatory hyperpigmentation.
What is sebum?
Sebum, a complex lipidic compound, is essential for maintaining the skin's barrier functions and hydration. A deficit in sebum production is synonymous with xerosis or atopy, leaving the skin vulnerable to allergens and micro-organisms.
On the contrary, hyperseborrhea provides an effective protective shield for the skin, but is nevertheless a breeding ground for acne in the event of oxidation.
Excessive sebum production is a necessary, but not sufficient condition. Indeed, the propensity of sebum to oxidise varies from one individual to another. Genetic, dietary, environmental or exogenous factors, such as pollution or the use of detergents, impact the quantity and quality of sebum.
Lipoperoxidation of squalene, a key lipid in the composition of sebum, is the beginning of a chain reaction involving follicular occlusion, hyperkeratinisation, microbial proliferation and inflammation. All of these factors are self-perpetuating and can lead to severe retentional acne.